Haploidentical Hematopoietic Stem Cell Transplantation for Acquired Severe Aplastic Anemia
نویسندگان
چکیده
منابع مشابه
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT...
متن کاملhematopoietic stem cell transplantation in patients with severe acquired aplastic anemia: iranian experience
introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...
متن کاملClinical applications of haploidentical hematopoietic stem cell transplantation in severe aplastic anemia.
OBJECTIVE The purpose of this study was to investigate the efficacy and safety of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) in severe aplastic anemia (SAA) and prophylaxis of complications involved. PATIENTS AND METHODS 8 patients with clinically diagnosed SAA (5 cases of SAA-I and 3 cases of SAA-II) were recruited, with the parents as the donors of hemopoiet...
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We examined if transplantation of combined haploidentical hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) affected graft failure and graft-versus-host disease (GVHD) in patients with severe aplastic anemia (SAA). Patients with SAA-I (N = 17) received haploidentical HSCT plus MSC infusion. Stem cell grafts used a combination of granulocyte colony-stimulating factor (G-CSF)-primed...
متن کاملAllogeneic hematopoietic stem cell transplantation in children with aplastic anemia.
The aim of this study was to prospectively investigate the efficacy and safety of fully matched allogeneic hematopoietic stem cell transplants in children with severe aplastic anemia in China. A total of twenty patients with severe aplastic anemia were enrolled in our study. Thirteen cases underwent transplantation with fully human leukocyte antigen (HLA)-matched, granulocyte-colony stimulating...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.3227.3227